Dra. Bruna Benso

Assistant Professor School of Dentistry Faculty of Medicine Pontificia Universidad Católica de Chile




(+56)2 3548184 / 8400




DDS, Universidade Paranaense, 2010

MSc in Dentistry, Universidade Estadual de Ponta Grossa, 2012

PhD in Dentistry, Universidade Estadual de Campinas, 2016

Postdoctoral Researcher in Phisiology, Universidad Austral de Chile, 2017-2020

Research area::

Pharmacology of bioactive products from natural source

Given their medical importance, natural products represent a tremendous source of drug discovery. For centuries, treatment with plants and/or their products was the only resource available to different ethnic groups for the prevention and treatment of many diseases. We pursuit to evaluate the pharmacological potential of natural compounds, co-products, metabolites and their derivatives using a guided pharmacological model. In particular, we are focused in the prevention and treatment of infectious and somatosensory nervous system related diseases derived from the stomatognathic complex. With the specific objective of evaluating products involved in a natural environment, it is an interest to evaluate their mechanisms of action at physiological, molecular and structural levels. The development of bioassay methods, new technologies and innovative products with a therapeutic approach and the use of pharmacologically active molecules from natural products are the focus of this research. Once the biological and toxicological bases of the naturally occurring compounds and/or derivatives are known, safe the therapeutic doses are determined for clinical trials and may be applied in Dentistry.

Publications during the last 5 years::

Benso B, Kovalik AC, Jorge JH, Campanha NH. Failures in the rehabilitation treatment with removable partial dentures. Acta Odontol Scand. 2013; 71: 1351-1355. doi: 10.3109/00016357.2013.777780. Review. PubMed PMID: 23834529. [IF: 1.1]

Freires IA, Denny C, Benso B, de Alencar SM, Rosalen PL. Antibacterial Activity of Essential Oils and Their Isolated Constituents against Cariogenic Bacteria: A Systematic Review. Molecules. 2015 Apr 22;20(4):7329- 58. doi: 10.3390/molecules20047329. Review. PubMed PMID: 25911964. [IF:2.8]

Benso B, Rosalen PL, Alencar SM, Murata RM. Malva sylvestris Inhibits Inflammatory Response in Oral Human Cells. An In Vitro Infection Model. PLoS One. 2015 Oct 19;10(10):e0140331. doi: 10.1371/journal.pone.0140331. eCollection 2015. PubMed PMID: 26479870; PubMed Central PMCID: PMC4610699. [IF:3.54]

Tiveron AP, Rosalen PL, Franchin M, Lacerda RC, Bueno-Silva B, Benso B, Denny C, Ikegaki M, Alencar SM. Chemical Characterization and Antioxidant, Antimicrobial, and Anti-Inflammatory Activities of South Brazilian Organic Propolis. PLoS One. 2016; 11(11):e0165588. doi: 10.1371/journal.pone.0165588. eCollection 2016. PubMed PMID: 27802316; PubMed Central PMCID: PMC5089781. [IF: 3.54]

Benso B, Franchin M, Massarioli AP, Paschoal JA, Alencar SM, Franco GC, Rosalen PL. Anti-Inflammatory, Anti-Osteoclastogenic and Antioxidant Effects of Malva sylvestris Extract and Fractions: In Vitro and In Vivo Studies. PLoS One. 2016; 11: e0162728. doi: 10.1371/journal.pone.0162728. eCollection 2016. PubMed PMID: 27643502; PubMed Central PMCID: PMC5028055. [IF: 3.54]

Seleem D, Chen E, Benso B, Pardi V, Murata RM. In vitro evaluation of antifungal activity of monolaurin against Candida albicans biofilms. PeerJ. 2016; 4: e2148. doi: 10.7717/peerj.2148. eCollection 2016. PubMed PMID: 27366648; PubMed Central PMCID: PMC4924139. [IF: 2.2]

Seleem D, Benso B, Noguti J, Pardi V, Murata RM. In Vitro and In Vivo Antifungal Activity of Lichochalcone- A against Candida albicans Biofilms. PLoS One. 2016; 11(6): e0157188. doi: 10.1371/journal.pone.0157188. eCollection 2016. PubMed PMID: 27284694; PubMed Central PMCID: PMC4902220. [IF: 3.54]

Benso B. Virulence factors associated with Aggregatibacter actinomycetemcomitans and their role in promoting periodontal diseases. Virulence. 2017 Feb 17;8(2):111-114. doi: 10.1080/21505594.2016.1235128. Epub 2016 Sep 13. PubMed PMID: 27623711; PubMed Central PMCID: PMC5354162. [IF: 4.66]

Research Grants (last 10 years).:

2017-2019. Postdoctorado CONICYT #3170518. Chalconas como nuevos y selectivos inhibidores de la actividad de TRPV1.

2017-2018. Proyecto DID UACh S-2017-03. Evaluación de la actividad farmacológica del extracto y fracciones de Malva sylvestris

2017-2018. Proyecto DID UACh S-2017-030. Efecto de la sedación consciente con óxido nitroso en la resolutividad de atención, satisfacción de los padres y control de niños de difícil manejo del centro de Clínicas Odontológicas de UACh, año 2017-2018. Estudio cohorte prospectivo.

2014-2015. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES. Beca de estudios para estudio en el exterior. Pasantía en la Ostrow School of Dentistry of USC (Los Angeles, CA, USA).

2013-2014. FAEPEX. Fundação de desenvolvimento da UNICAMP. Proyecto: Estudio in vitro de la actividad antiinflamatoria de las propolis orgânicas en macrófagos estimulados por LPS. Responsable: Dr. Pedro Rosalen. Colaboradores: Bruna Benso, Marcelo Franchin, Carina Denny.

2012-2016. Doctorado. Fundação Aperfeiçoamento de Pessoal de Nível Superior – FAPESP #2011-23980-5. Evaluación de la capacidad antimicrobiana, antiinflamatória, remodelación ósea, antioxidante y antiproliferativo de Malva sylvestris.

Pontificia Universidad Católica de Chile 2024

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