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Publicaciones Científicas Internacionales - ISI Profesores Carrera de Odontología UC.



Smith PC. Role of myofibroblasts in normal and pathological periodontal wound healing. Oral Diseases. In Press.

Saldías MP, Fernández C, Morgan A, Díaz C, Morales D, Jaña F, Gómez A, Silva A, Briceño F, Oyarzún A, Maldonado F, Cerda O, Smith PC, Cáceres M. Aged blood factors decrease cellular responses associated with delayed gingival wound repair. PLoS One. 2017 Sep 12;12(9):e0184189. doi: 10.1371/journal.pone.0184189. eCollection 2017.

Pavez L, Tobar N, Chacón C, Arancibia R, Martínez C, Tapia C, Pastor A, González M, Martínez J,Smith PC. Chitosan-Triclosan Particles Modulate Inflammatory Signaling In Gingival Fibroblasts. Journal of Periodontal Research. In Press.

Retamal IN, Hernández R, Melo F, Zapata P, Martínez C, Martínez J, Smith PC. Glycated Collagen Stimulates Differentiation of Gingival Myofibroblasts. J Periodontol. 2017; 88: 926-935. doi:10.1902/jop.2017.160730.

Lopez R, Smith PC, Gostemeyer G, Schwendicke F. Ageing, dental caries and periodontal diseases. J Clin Periodontol 2017; 44 (Suppl. 18): S145–S152. doi: 10. 1111/jcpe.12683.

Tobar N, Porras O, Smith PC, Barros LF, Martínez J. Modulation of Mammary Stromal Cell Lactate Dynamics by Ambient Glucose and Epithelial Factors. J Cell Physiol. 2017 Jan; 232(1): 136-144. doi:10.1002/jcp.25398.

Kallens V, Tobar N, Molina J, Bidegain A, Smith PC, Porras O, Martínez J. Glucose Promotes a Pro-Oxidant and Pro-Inflammatory Stromal Microenvironment which Favors Motile Properties in Breast Tumor Cells. J Cell Biochem. 2017; 118: 994-1002. doi: 10.1002/jcb.25650.

Farina R., Bravo R., Villanueva R., Valladares S., Hinojosa A., Martinez B. Measuring the condylar unit in condylar hyperplasia: from the sigmoid notch or from the mandibular lingula?. Int. J. Oral Maxillofac. Surg. 2017; 46: 857–860.

Gallego F, Larroulet C, Palomer L, Repetto A, Verdugo D. Socioeconomic inequalities in self-perceived oral health among adults in Chile. International Journal for Equity in Health. 2017; 16(1):23.


Tobar N, Porras O, Smith PC, Barros LF, Martínez J. Modulation of Mammary Stromal Cell Lactate Dynamics by Ambient Glucose and Epithelial Factors. J Cell Physiol. 2017 Jan; 232(1): 136-144. doi:10.1002/jcp.25398. 

Kallens V, Tobar N, Molina J, Bidegain A, Smith PC, Porras O, Martínez J. Glucose Promotes a Pro-Oxidant and Pro-Inflammatory Stromal Microenvironment which Favors Motile Properties in Breast Tumor Cells. J Cell Biochem. 2016 Jul 12. doi: 10.1002/jcb.25650. [Epub ahead of print] 

Retamal IN, Hernández R, González-Rivas C, Cáceres C, Arancibia R, Romero A, Martínez C, Tobar N, Martínez J, Smith PC.  Methylglyoxal and methylglyoxal-modified collagen as inducers of cellular injury in gingival connective tissue cells. Journal of Periodontal Research. 2016 Dec;51(6):812-821. doi: 10.1111/jre.12365. 

Martinez C, Gonzalez S, Palma V, Smith PC. Platelet Poor Plasma and Platelet Rich Plasma Stimulate Bone Lineage Differentiation in Periodontal Ligament Stem Cells. Journal of Periodontology 2016; 87(2):e18-26. doi: 10.1902/jop.2015.150360. 

Luque-Martinez I, Reis A, Schroeder M, Muñoz MA, Loguercio AD, Masterson D, Maia LC. Comparison of efficacy of tray-delivered carbamide and hydrogen peroxide for at-home bleaching: a systematic review and meta-analysis. Clin Oral Investig. 2016 Jun 11.

Mena-Serrano AP, Garcia E, Luque-Martinez I, Grande R, Loguercio AD, Reis A. A Single-Blind Randomized Trial About the Effect of Hydrogen Peroxide Concentration on Light-Activated Bleaching. Oper Dent. 2016 Jun 28.

Hass V, Luque-Martinez I, Muñoz MA, Reyes MF, Abuna G, Sinhoreti MA, Liu AY, Loguercio AD, Wang Y, Reis A. The effect of proanthocyanidin-containing 10% phosphoric acid on bonding properties and MMP inhibition. Dent Mater. 2016 Mar;32(3):468-75. 

Hass V, Luque-Martinez IV, Gutierrez MF, Moreira CG, Gotti VB, Feitosa VP, Koller G, Otuki MF, Loguercio AD, Reis A. Collagen cross-linkers on dentin bonding: Stability of the adhesive interfaces, degree of conversion of the adhesive, cytotoxicity and in situ MMP inhibition. Dent Mater. 2016 Jun;32(6):732-41. 

Simões TC, Luque-Martinez Í, Moraes RR, Sá A, Loguercio AD, Moura SK. Longevity of Bonding of Self-adhesive Resin Cement to Dentin. Oper Dent. 2016 Feb 26. 

Hass V, de Paula AM, Parreiras S, Gutiérrez MF, Luque-Martinez I, de Paris Matos T, Bandeca MC, Loguercio AD, Yao X, Wang Y, Reis A. Degradation of dentin-bonded interfaces treated with collagen cross-linking agents in a cariogenic oral environment: An in situ study. J Dent. 2016 Jun;49:60-7. 

Loguercio AD, Hass V, Gutierrez MF, Luque-Martinez IV, Szezs A, Stanislawczuk R, Bandeca MC, Reis A. Five-year Effects of Chlorhexidine on the In Vitro Durability of Resin/Dentin Interfaces. J Adhes Dent. 2016;18(1):35-42. 

Palomer L. Inequidades en Salud Bucal. Factores que Determinan su Realidad en Chile" en la revista Acta Bioethica, 2016; 22 (2): 315-319. 


Palomer L. López R. "Educación universitaria, formando profesionales y personas." FEM. Revista de la Fundación Educación Médica 19.6 (2016): 281-285



Publicaciones Científicas Internacionales ISI

Loguercio AD, Luque-Martinez I, Lisboa AH, Higashi C, Queiroz VO, Rego RO, Reis A. Influence of Isolation Method of the Operative Field on Gingival Damage, Patients' Preference, and Restoration Retention in Noncarious Cervical Lesions. Oper Dent. 2015 Nov-Dec;40(6):581-93. doi: 10.2341/14-089-C. Epub 2015 Jul 9. PubMed PMID: 26158415. 

Sezinando A, Luque-Martinez I, Muñoz MA, Reis A, Loguercio AD, Perdigão J. Influence of a hydrophobic resin coating on the immediate and 6-month dentin bonding of three universal adhesives. Dent Mater. 2015 Oct;31(10):e236-46. doi:10.1016/ Epub 2015 Jul 23. PubMed PMID: 26211697.

Martínez CE, González SA, Palma V, Smith PC. Platelet Poor Plasma and Platelet Rich Plasma Stimulate Bone Lineage Differentiation in Periodontal Ligament Stem Cells. J Periodontol 2015; 14:1-14. [Epub ahead of print]

Smith PC, Martínez C, Cáceres M, Martínez J. Research on growth factors in periodontology. Periodontol 2000. 2015; 67: 234-250.

Smith PC, Cáceres M, Martínez C, Oyarzún A, Martínez J. Gingival Wound Healing: An Essential Response Disturbed by Aging? J Dent Res. 2015; 94: 395-402.

Romero A, Cáceres M, Arancibia R, Silva D, Couve E, Martínez C, Martínez J, Smith PC. Cigarette smoke condensate inhibits collagen gel contraction and prostaglandin E2 production in human gingival fibroblasts. J Periodontal Res 2015; 50: 371-379. 

Martínez C, Smith P, Palma V. The influence of platelet- derived products on angiogenesis and tissue repair: a concise update. Front. Physiol. 6:290. DOI: 10.3389/fphys.2015.00290


Publicaciones Scielo

Palomer L, López R. Medición de los valores éticos y morales enseñados en la carrera de Odontología de la Pontificia Universidad Católica de Chile, desde la apreciación docente” Revista FEM Fundación Educación Médica 2016; 19: 77-84.



Lee-Liu D, Moreno M, Almonacid LI, Tapia VS, Muñoz R, von Marées J, Gaete M, Melo F, Larraín J. Genome-wide expression profile of the response to spinal cord  injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative stages. Neural Dev. 2014 May 22;9:12. doi: 10.1186/1749-8104-9-12.

Tobar N, Avalos MC, Méndez N, Smith PC, Bernabeu C, Quintanilla M, Martínez J. Soluble MMP-14 produced by bone marrow-derived stromal cells sheds epithelial endoglin modulating the migratory properties of human breast cancer cells. Carcinogenesis. 2014 Aug;35(8):1770-9. doi: 10.1093/carcin/bgu061. 

Cáceres M, Oyarzun A, Smith PC. Defective Wound-healing in Aging Gingival Tissue. J Dent Res. 2014 Apr 28;93(7):691-697.

Tobar N, Toyos M, Urra C, Méndez N, Arancibia R, Smith PC, Martínez J.c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells. BMC Cancer. 2014 Aug 30;14:640. doi: 10.1186/1471-2407-14-640.



Wells KL, Gaete M, Matalova E, Deutsch D, Rice D, Tucker AS. Dynamic relationship of the epithelium and mesenchyme during salivary gland initiation: the role of Fgf10. Biol Open. 2013 Aug 9;2(10):981-9. doi: 10.1242/bio.20135306.eCollection 2013. 

Arancibia R, Maturana C, Silva D, Tobar N, Tapia C, Salazar JC, Martínez J, Smith PC. Effects of chitosan particles in periodontal pathogens and gingival fibroblasts. Journal of Dental Research 2013: 92: 740-745. 

Gaete M1, Tucker AS. Organized emergence of multiple-generations of teeth in snakes is dysregulated by activation of Wnt/beta-catenin signalling. PLoS One. 2013 Sep 3;8(9):e74484. 

Alfaqeeh SA, Gaete M, Tucker AS. Interactions of the tooth and bone during development. Journal of Dental Research 2013; 92: 1129-1135. 

Inzunza D, Covarrubias C, Marttens AV, Leighton Y, Carvajal JC, Valenzuela F, Díaz-Dosque M, Méndez N, Martínez C, Pino AM, Rodríguez JP, Cáceres M, Smith P. 2013. Synthesis of nanostructured porous silica coatings on titanium and their cell adhesive and osteogenic differentiation properties. J Biomed Mater Res Part A 2013 Apr 9. doi: 10.1002/jbm.a.34673. 

Silva D, Arancibia R, Tapia C, Acuña-Rougier C, Diaz-Dosque M, Cáceres M, Martínez J, Smith PC. Chitosan and Platelet-derived growth factor synergistically stimulate cell proliferation in gingival fibroblasts. Journal of Periodontal Research.2013; 48: 677-686.



Palomer L. Aspectos éticos relacionados con las remuneraciones en Odontología. Acta Bioethica 2012; 18: 267-271.

Valenzuela F, Covarrubias C, Martínez C, Smith P, Díaz-Dosque M, Yazdani-Pedram M. Preparation and bioactive properties of novel bone-repair bionanocomposites based on hydroxyapatite and bioactive glass nanoparticles. J Biomed Mater Res B Appl Biomater. 2012; 100: 1672-1682. 

Arancibia R, Oyarzún A, Silva D, Tobar N, Martínez J, Smith PC. TNF-alpha inhibits TGF-beta-stimulated myofibroblastic differentiation and extracellular matrix production in human gingival fibroblasts. Journal of Periodontology. 2013; 84(5): 683-693. 

Silva D, Cáceres M, Arancibia R, Martínez C, Martínez J, Smith PC. Effects of cigarette smoke and nicotine on cell viability, migration and myofibroblastic differentiation. Journal of Periodontal Research 2012; 47: 559-607. 

Cáceres M, Martínez C, Martínez J, Smith PC. Effects of Platelet Rich and Poor Plasma on the reparative response of gingival fibroblasts. Clinical Oral Implants Research. 2012; 23: 1104-1111.



Cáceres M, Romero A, Copaja M, Díaz-Araya G, Martínez J, Smith PC. Simvastatin alters fibroblastic cell responses involved in tissue repair. J Periodontal Res 2011; 46: 456–463.

Martínez C, Smith PC, Rodriguez JP. Palma P. Sonic Hedgehog stimulates Proliferation of Human Ligament Periodontal Stem Cells. Journal of Dental Research 2011; 90: 483-488.



Tobar N, Guerrero J, Smith PC, Martínez J. NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration. Br J Cancer 2010; 103: 1040-1047.

Oyarzún AD, Arancibia R, Hidalgo R, Peñafiel C, Cáceres M, González MJ, Martínez J, Smith PC. Involvement of MT1-MMP and TIMP-2 in human periodontal disease. Oral Diseases. 2010; 16: 388-395.

Guerrero J, Tobar N, Cáceres M, Espinoza L, Escobar P, Dotor J, Smith PC, Martínez J. Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human and mice adipose cells. Possible role of TGF-β1 and TNF-α. Breast Cancer Res Treat. 2010; 119: 497-508.



Palomer L. "Consentimiento informado en Odontología. Un análisis teórico-práctico". Acta Bioethica 2009; 15: 100-105.

Arancibia R, Cáceres M, Martínez J, Smith PC. Triclosan inhibits Tumor Necrosis factor-alpha stimulated urokinase production in human gingival fibroblasts. J Periodontal Res. 2009; 44: 726-735.

Gonzalez R, Arancibia R, Cáceres M, Martínez J, Smith PC. Cigarette smoke condensate stimulates urokinase production through the generation of reactive oxygen species and activation of the mitogen activated protein kinase pathways in human gingival fibroblasts. J Periodontal Res 2009; 44: 386-394.

Smith PC, Guerrero J, Tobar N, Cáceres M, González MJ, Martínez J. Tumor necrosis factor--stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts. J Periodontal Res 2009; 44: 73-80.



Tobar N, Cáceres M, Santibáñez JF, Smith PC, Martínez J. RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NFkappaB-dependent mechanism. Cancer Lett 2008; 267:125-132.

Cáceres M, Hidalgo R, Sanz A, Martínez J, Riera P, Smith PC. Effect of platelet-rich plasma on cell adhesion, cell migration, and myofibroblastic differentiation in human gingival fibroblasts. J Periodontol 2008; 79: 714-720. 

Cáceres M, Tobar N, Guerrero J, Smith PC, Martínez J. c-jun-NH2JNK mediates invasive potential and EGFR activation by regulating the expression of HB-EGF in a urokinase-stimulated pathway. J Cell Biochem 2008 15; 103: 986-993.

Publicaciones Scielo y otros

Palomer L, Humeres P, Sanchez A, González M, Contreras A. Una experiencia de Aprendizaje Servicio: fomentando el desarrollo de valores en estudiantes de odontología chilenos”. Fundación Educación Médica 2013; 16 (2): 91-96.

Rioseco M, Balestrini C, Ramirez H, Cerutti C. Glositis romboidal media: revisión a propósito de un caso clínico. Revista de Dermatología Chilena, 2012;28(3):296-299.

Rioseco M, Balestrini C, Solar A, Delpiano AM. Mucocele de las glandulas Blandin - Nuhn, aspectos patológicos, terapéuticos, a proposito de dos casos clínicos. Rev Chilena Dermatol 2012; 28(3): 300-304. 

Palomer L, García H. ¿Es Importante la Salud Oral en los Niños con Diabetes? Revista Chilena de Pediatría 2010; 81 (1): 64-70.

Droguetti P, Cruzat F, Smith P, Oyarzún A. Participación de MT1-MMP en la remodelación del ligamento periodontal durante la movilización dentaria. Rev Clin Periodoncia Implantol Rehabil Oral 2010; 3: 113-117.

Boza Y, Yefi R, Rudolph MI, Smith PC, Oberyszyn TM, Tober KL, Rojas IG. Single exposure of human mucosa fibroblasts to ultraviolet B radiation reduces proliferation and induces COX-2 expression and activation. Rev Clin PeriodonciaImplantol Rehabil Oral 2010; 3: 123-127.

Smith PC, Arancibia R, Martínez J. Empleo de agentes farmacológicos en dentífricos como moduladores de la infección e inflamación periodontal. Rev Clin Periodoncia Implantol Rehabil Oral 2008; 1: 101-103.


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